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Parks, John
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Academic Article Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys.
Academic Article Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.
Academic Article Dietary fish oil effects on biliary lipid secretion and cholesterol gallstone formation in the African green monkey.
Academic Article Reduced proteoglycan binding of low density lipoproteins from monkeys (Macaca fascicularis) fed a fish oil versus lard diet.
Academic Article Isolation and characterization of high density lipoprotein apoproteins in the non-human primate (vervet).
Academic Article Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.
Academic Article Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains.
Academic Article Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women.
Academic Article Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers.
Academic Article Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.
Academic Article HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney.
Academic Article Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
Academic Article Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone.
Academic Article Effect of dietary fish oil on coronary artery and aortic atherosclerosis in African green monkeys.
Academic Article Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation.
Academic Article Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Academic Article Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Academic Article The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction.
Academic Article LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Academic Article Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons.
Academic Article Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
Academic Article Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis.
Academic Article Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11.
Academic Article Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
Academic Article Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation.
Academic Article Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation.
Academic Article The effect of ACACB cis-variants on gene expression and metabolic traits.
Academic Article Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo.
Academic Article Hepatic ABCA1 and VLDL triglyceride production.
Academic Article Contraceptive steroid effects on lipids and lipoproteins in cynomolgus monkeys.
Academic Article Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.
Academic Article Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions.
Academic Article An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.
Academic Article Lecithin:cholesterol acyltransferase-induced modifications of liver perfusate discoidal high density lipoproteins from African green monkeys.
Academic Article Effect of fish oil versus lard diets on the chemical and physical properties of low density lipoproteins of nonhuman primates.
Academic Article Interactions of the carboxyl group of oleic acid with bovine serum albumin: a 13C NMR study.
Academic Article Physical characterization of lymph chylomicrons and very low density lipoproteins from nonhuman primates fed saturated dietary fat.
Academic Article ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys.
Academic Article Dietary fish oil-induced decrease in low density lipoprotein binding to fibroblasts is mediated by apolipoprotein E.
Academic Article Effect of interleukin-1 alpha on lipoprotein lipids in cynomolgus monkeys: comparison to tumor necrosis factor.
Academic Article Dietary fish oil modification of cynomolgus monkey low density lipoproteins results in decreased binding and cholesteryl ester accumulation by cultured fibroblasts.
Academic Article Glycosylation structure and enzyme activity of lecithin:cholesterol acyltransferase from human plasma, HepG2 cells, and baculoviral and Chinese hamster ovary cell expression systems.
Academic Article Amino acid residue 149 of lecithin:cholesterol acyltransferase determines phospholipase A2 and transacylase fatty acyl specificity.
Academic Article Influence of vesicle surface composition on the interfacial binding of lecithin:cholesterol acyltransferase and apolipoprotein A-I.
Academic Article Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase.
Academic Article Small HDL particles containing two apoA-I molecules are precursors in vivo to medium and large HDL particles containing three and four apoA-I molecules in nonhuman primates.
Academic Article Lysosomal acid lipase mutations that determine phenotype in Wolman and cholesterol ester storage disease.
Academic Article Phosphatidylcholine fluidity and structure affect lecithin:cholesterol acyltransferase activity.
Academic Article ApoA-I secretion from HepG2 cells: evidence for the secretion of both lipid-poor apoA-I and intracellularly assembled nascent HDL.
Academic Article Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase.
Academic Article Identification of the lipoprotein initiating domain of apolipoprotein B.
Academic Article Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3.
Academic Article Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.
Academic Article Prebeta high density lipoprotein has two metabolic fates in human apolipoprotein A-I transgenic mice.
Academic Article ATP-binding cassette transporter AI and its role in HDL formation.
Academic Article Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins.
Academic Article Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Academic Article Effect of fish oil on atherosclerosis and lipoprotein metabolism.
Academic Article Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Academic Article Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice.
Academic Article A rapid and sensitive micro-assay for the enzymatic determination of plasma and lipoprotein cholesterol.
Academic Article Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1.
Academic Article Whole-body cholesterol metabolism in cholesterol-fed African green monkeys with a variable hypercholesterolemic response.
Academic Article Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice.
Academic Article Mechanisms by which botanical lipids affect inflammatory disorders.
Academic Article Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages.
Academic Article Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL.
Academic Article Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis.
Academic Article LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.
Academic Article Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Academic Article Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
Academic Article An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2.
Academic Article Apolipoprotein M expression increases the size of nascent pre beta HDL formed by ATP binding cassette transporter A1.
Academic Article ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Academic Article ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions.
Academic Article A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion.
Academic Article Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin: cholesterol acyltransferase and lipase deficiency.
Academic Article An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.
Academic Article Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.
Academic Article The reactivity of plasma phospholipids with lecithin:cholesterol acyltransferase is decreased in fish oil-fed monkeys.
Academic Article Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans.
Academic Article Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice.
Academic Article CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.
Academic Article Hepatic ABC transporters and triglyceride metabolism.
Academic Article Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers.
Academic Article Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection.
Academic Article ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development.
Academic Article Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.
Academic Article Low density lipoproteins in atherosclerosis.
Academic Article Studies of low density lipoprotein molecular weight in human beings with coronary artery disease.
Academic Article Detection of immunological heterogeneity of an isolated, purified protein (vervet apolipoprotein A-I).
Academic Article The ionization behavior of fatty acids and bile acids in micelles and membranes.
Academic Article 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates.
Academic Article Compared with dietary monounsaturated and saturated fat, polyunsaturated fat protects African green monkeys from coronary artery atherosclerosis.
Academic Article Portacaval shunt and whole-body cholesterol metabolism in the cholesterol-fed African green monkey.
Academic Article Decreased binding of apoA-I to phosphatidylcholine monolayers containing 22:6 n-3 in the sn-2 position.
Academic Article High level secretion of wild-type and mutant forms of human proapoA-I using baculovirus-mediated Sf-9 cell expression.
Academic Article The effects of testosterone on lipids and eicosanoids in cynomolgus monkeys.
Academic Article Alteration in apolipoprotein A-I 22-mer repeat order results in a decrease in lecithin:cholesterol acyltransferase reactivity.
Academic Article Effects of contraceptive estrogen and progestin on the atherogenic potential of plasma LDLs in cynomolgus monkeys.
Academic Article The hydrophobic face orientation of apolipoprotein A-I amphipathic helix domain 143-164 regulates lecithin:cholesterol acyltransferase activation.
Academic Article Lecithin-cholesterol acyltransferase. Assay of cholesterol esterification and phospholipase A2 activities.
Academic Article Determination of the tissue sites responsible for the catabolism of large high density lipoprotein in the African green monkey.
Academic Article Vesicle-binding properties of wild-type and cysteine mutant forms of alpha(1) domain of apolipoprotein B.
Concept NFATC Transcription Factors
Concept Humans
Concept Cattle
Concept Child
Concept Primates
Concept Biological Transport
Concept Cyclic AMP Response Element-Binding Protein
Concept Cricetinae
Concept Blood Glucose
Concept beta-Cyclodextrins
Concept ATP-Binding Cassette Transporters
Concept Feeding Behavior
Concept Benzoates
Concept Haplorhini
Concept Binding Sites
Concept Adipocytes, Brown
Concept Animals
Concept Binding, Competitive
Concept Blotting, Northern
Concept Regional Blood Flow
Concept Aged
Concept Sterol Regulatory Element Binding Protein 1
Concept Chronic Disease
Concept African Continental Ancestry Group
Concept Demography
Concept Double-Blind Method
Concept Mice, Knockout
Concept Baculoviridae
Concept Adolescent
Concept Blotting, Western
Concept Butter
Concept Biopsy
Concept Onions
Concept Mice
Concept Bone Marrow Cells
Concept Models, Biological
Concept Chromosomes, Artificial, Bacterial
Concept rab3A GTP-Binding Protein
Concept Adult
Concept Mice, Inbred C57BL
Concept Indians, North American
Concept Computational Biology
Concept Tobacco
Concept Mice, Transgenic
Concept Cercopithecus
Concept Drosophila
Concept Bile Acids and Salts
Concept Body Mass Index
Concept Protein Binding
Concept Hispanic Americans
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept DNA-Binding Proteins
Concept Postural Balance
Concept Bile
Concept Transients and Migrants
Concept NF-kappa B
Concept High-Density Lipoproteins, Pre-beta
Concept Serum Albumin, Bovine
Concept Brain
Concept Aged, 80 and over
Concept Emigrants and Immigrants
Concept Infant
Concept Macaca fascicularis
Concept Apolipoprotein B-100
Concept Blood Vessels
Concept Sterol Regulatory Element Binding Protein 2
Concept Mice, Inbred BALB C
Concept Body Weight
Concept Mice, Obese
Concept Bone Marrow Transplantation
Concept Mice, Nude
Concept Papio
Concept Adenoviridae
Concept Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Concept Rats
Concept African Americans
Concept Breast Neoplasms
Concept Middle Aged
Concept Buffers
Concept Rats, Sprague-Dawley
Concept Swine
Concept Mice, Inbred DBA
Concept Genetic Vectors
Concept European Continental Ancestry Group
Concept Whole-Body Irradiation
Concept Benzylamines
Concept Echium
Concept Behavior
Concept Base Sequence
Concept Thromboxane B2
Concept Blood Protein Electrophoresis
Concept Listeria monocytogenes
Concept Body Composition
Concept Mice, Mutant Strains
Academic Article Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.
Academic Article Increased cholesterol content in gammadelta (?d) T lymphocytes differentially regulates their activation.
Academic Article Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice.
Academic Article Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.
Academic Article Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models.
Academic Article Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice.
Academic Article Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.
Academic Article An abundant dysfunctional apolipoprotein A1 in human atheroma.
Academic Article Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Academic Article Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys.
Academic Article Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development.
Academic Article Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.
Academic Article Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.
Academic Article Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver.
Academic Article Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
Academic Article Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.
Academic Article LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
Academic Article Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.
Academic Article Characterization of circulating APOL1 protein complexes in African Americans.
Academic Article A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.
Academic Article Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.
Academic Article MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Academic Article APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction.
Academic Article Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression.
Academic Article In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.
Academic Article Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes.
Grant EFFECT OF N-3 FATTY ACIDS ON HDL LIPID INTERACTION
Grant DIETARY PUFA AND HDL SUBFRACTION METABOLISM
Grant Regulation of ApoB Lipoprotein Expansion and Hepatic Lipid Efflux by ApoA-IV
Grant Hepatocyte Abca1, cholesterol trafficking, and lipid mobilization
Grant Macrophage, ABCA1, Inflammation, and Atherosclerosis
Grant ATHEROGENIC PROPERTIES OF LOW DENSITY LIPOPROTEINS
Grant Integrative Lipid Metabolism, Inflammation, and Chronic Diseases
Grant 2016 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Seminar
Academic Article Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.
Academic Article Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.
Academic Article Genetic regulation of adipose tissue transcript expression is involved in modulating serum triglyceride and HDL-cholesterol.
Academic Article Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.
Academic Article Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.
Academic Article ?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.
Academic Article Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.
Academic Article LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.
Academic Article Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.
Academic Article Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
Academic Article Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice.
Award or Honor Receipt Established Investigator in Basic Science Award
Academic Article Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans.
Academic Article Plasma apoM and S1P levels are inversely associated with mortality in African Americans with type 2 diabetes mellitus.
Academic Article Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.
Academic Article Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
Academic Article Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis.
Academic Article Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake.
Academic Article Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.
Academic Article Identification of Plasma Glycosphingolipids as Potential Biomarkers for Prostate Cancer (PCa) Status.
Academic Article APOL1 Kidney-Risk Variants Induce Mitochondrial Fission.
Academic Article Effect of quercetin on nonshivering thermogenesis of brown adipose tissue in high-fat diet-induced obese mice.
Academic Article Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates Atherosclerosis in LDL Receptor-Deficient Mice.
Academic Article Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction.
Academic Article Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.
Academic Article Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.
Academic Article Monocyte miRNAs are Associated with Type 2 Diabetes.
Academic Article Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Academic Article Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury.
Academic Article Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSMRO.
Academic Article Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without effects on body composition.
Academic Article The effects of brewers' spent grain on high-fat diet-induced fatty liver.
Academic Article APOL1 Risk Variants Impair Multiple Mitochondrial Pathways in a Metabolomics Analysis.
Academic Article Multi-omics Analyses Identify AKR1A1 as a Biomarker for Diabetic Kidney Disease.
Academic Article Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids.
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